李海鹏，博士，中科院上海生科院计算生物学研究所研究员。

我们研究组长期致力于群体遗传学的理论分析研究，我们的目标是研究生物由于正选择的作用而产生的适应现象。这些研究能够帮助我们深入了解基因的功能以及基因和环境的相互作用。针对先导专项中的三个关键性状，为了能够进一步研究正选择发生的分子生物学机制，我们研究组提出了一系列的理论方法和研究策略，以避免因为种群数量变化和群体结构等混淆因素的存在，常用的检测方法出现的很高的假阳性率。从而在统计学意义上保证候选基因的可靠性，进而提高后续试验的成功率，节约宝贵的实验经费。

实验室网站: http://www.picb.ac.cn/evolgen/

1.LI Junrui, SCHNEIDER Kristan A., LI Haipeng*(2013). The Hitchhiking Effect of a Strongly Selected Substitution in Male Germline on Neutral Polymorphism in a Monogamy Population. PLoS ONE 8(8):e71497.

2.LIN Kao, FUTSCHIK Andreas, LI Haipeng*(2013). A fast estimate for the population recombination rate based on regression. Genetics doi:10.1534/genetics.113.150201.

3.LI Haipeng, WIEHE Thomas(2013). Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation. PLoS Comput Biol 9: e1003060.

4.LI Biqing, YOU Jin, CHEN Lei, ZHANG Jian, ZHANG Ning, LI Haipeng, HUANG Tao, KONG Xiangyin, CAI Yudong(2013). Identification of lung cancer related genes with the shortest path approach in a protein-protein interaction network. BioMed Research International (in press).

5.NIU Shen, HUANG Tao, FENG Kaiyan, HE Zhisong, CUI Weiren, GU Lei, LI Haipeng, CAI Yudong, LI Yixue (2013). Inter- and intra-chain disulfide bond prediction based on optimal feature selection. Protein & Peptide Letters 20:324-335.

6.NIU Bing, YUAN Xiaocheng, ROEPER Preston, SU Qiang, PENG Chunrong, YIN Jingyuan, DING Juan, LI Haipeng*, LU Wencong (2013). HIV-1 protease cleavage site prediction based on two-stage feature selection method. Protein & Peptide Letters 20:290-298.

7.ONGE Kate R.St., FOXE John Paul, LI Junrui, LI Haipeng, HOLM Karl, CORCORAN Pádraic, SLOTTE Tanja, LASCOUX Martin, WRIGHT Stephen I.(2012). Coalescent-based analysis distinguishes between allo- and autopolyploid origin in Shepherd's Purse (Capsella bursa-pastoris). Mol Biol Evol 29:1721-1733.

8.LI Junrui, LI Haipeng, JAKOBSSON Mattias, LI Sen, SJÖDIN Per, LASCOUX Martin (2012). Joint analysis of demography and selection in population genetics: where do we stand and where could we go? Mol Ecol 21:28-44.

9.WANG Kai, HU Lele, SHI Xiaohe, DONG Yingsong, LI Haipeng*, WEN Tieqiao (2012). PSCL: Predicting protein subcellular localization based on optimal functional domains. Protein & Peptide Letters 19:15-22.

10.LI Zhonghu, ZOU Jiabin, MAO Kangshan, LIN Kao, LI Haipeng, LIU Jianquan, Källman Thomas, LASCOUX Martin (2012). Population genetic evidence for complex evolutionary histories of four high altitude Juniper species in the QinHai-Tibetan Plateau. Evolution 66:831-845.

11.LI Haipeng* (2012). Beyond our naked eyes. J Mol Cell Biol 4:63.

12.HU Lele, LI Zhen, WANG Kai, NIU Shen, SHI Xiaohe, CAI Yudong, LI Haipeng* (2011). Prediction and analysis of protein methylarginine and methyllysine based on multisequence features. Biopolymers 95:763-771.

13.HUANG Tao, WAN Sibao, XU Zhongping, ZHENG Yufang, FENG Kai-Yan, LI Haipeng*, KONG Xiangyin, CAI Yudong (2011). Analysis and prediction of translation rate based on sequence and functional features of the mRNA. PLoS ONE 6:e16036.

14.LIN Kao, LI Haipeng*, SCHLÖTTERER Christian, FUTSCHIK Andreas (2011). Distinguishing positive selection from neutral evolution: boosting the performance of summary statistics. Genetics 187:229-244.

15.LI Haipeng* (2011). A new test for detecting recent positive selection that is free from the confounding impacts of demography. Mol Biol Evol 28:365-375.

16.LU Lingyi, LIN Kao, QIAN Ziliang, LI Haipeng*, CAI Yudong, LI Yixue (2011). Predicting DNA methylation status using word composition. J. Biomedical Science and Engineering 3:672-676.

17.CHEN Lei, FENG Kaiyan, CAI Yudong, CHOU Kuochen, LI Haipeng* (2010). Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition. BMC Bioinformatics 11:293.

18.LIN Kao, QIAN Ziliang, LU Lin, LU Lingyi, LAI Lihui, GU Jieyi, ZENG Zhenbing, LI Haipeng*, CAI Yudong (2010). Predicting miRNA's target from primary structure by the nearest neighbor algorithm. Mol Divers 14:719-729.

19.LI J, YANG H, LI Junrui, LI Haipeng, NING T, PAN XR, SHI P, ZHANG YP (2010). Artificial selection of the melanocortin receptor 1 gene in Chinese domestic pigs during domestication. Heredity 105:274-281.

20.LIN Kao, LI Haipeng* (2009). Advances in detecting positive selection on genome. Hereditas(Beijing) 31:896-902.

21.XU Huijun, LI Junrui, LI Haipeng* (2009). Application of differential equation to the evolution of two groups. Zoological Research 30:11-16.

22.LU Lingyi, QIAN Ziliang, SHI Xiaohe, LI Haipeng*, CAI Yudong, LI Yixue (2009). A knowledge-based method to predict the cooperative relationship between transcription factors. Mol Divers 14:815-819.

23.LU Lin, SHI Xiaohe, LI Sujun, XIE Zhiqun, FENG Yongli, LU Wencong, LI Yixue, LI Haipeng*, CAI Yudong (2009). Protein sumoylation sites prediction based on two-stage feature selection. Mol Divers 14:81-86.

24.ZHANG Wen, CAI Wangwei, ZHOU Weiping, LI Haipeng, LI Liang, YAN Wei, DENG Qinkai, ZHANG Yaping, FU Yunxin, XU Xiangmin (2008). Evidence of gene conversion in the evolutionary process of the codon 41/42 (-CTTT) mutation causing β-Thalassemia in Southern China. J Mol Evol 66:436-445.