陈洛南，中国科学院上海生命科学研究院系统生物学重点实验室执行主任、研究员。

项目四负责人（关键理论和模型的研发与支撑），项目四课题7组长（大数据的系统生物学及网络分析）

主要从事计算系统生物学的研究工作，近年，在此领域发表期刊论文200余篇，为中国运筹学会《计算系统生物学分会》理事长，IEEE-SMC《系统生物学委员会》主席。在此专项，主要负责在网络层次建立研究复杂性状的eGPS理论框架，揭示动物复杂性状形成过程中的关键节点，发现驱动复杂性状调控网络转变的关键因子，确定实现复杂性状转变的关键子网络。

实验室网站： http://www.sysbio.ac.cn/cb/chenlab/LuonanChen.htm

通讯地址： 上海市岳阳路320号细胞大楼系统生物学重点实验室

电话: 021-5492-0100

Email: lnchen@sibs.ac.cn

1. Rui Liu, Xiangtian Yu , Xiaoping Liu, Dong Xu, Kazuyuki Aihara and Luonan Chen. Identifying critical transitions of complex diseases based on a single sample. Bioinformatics, DOI:10.1093/bioinformatics/btu084, 2014.

2. B.Liu, Z.Yuan, K.Aihara, L.Chen. Reinitiation enhances reliable transcriptional responses in eukaryotes. J. R. Soc. Interface, 20140326, 2014.

3. Fang-Xiang Wu, Lin Wu, Jianxin Wang, Juan Liu, Luonan Chen. Transittability of complex networks and its applications to regulatory biomolecular networks. Scientific Reports, DOI: 10.1038/srep04819,2014.

4. Tao Zeng, Chuan-chao Zhang, Wanwei Zhang, Rui Liu, Juan Liu, Luonan Chen. Deciphering early development of complex diseases by progressive module network. Methods, http://dx.doi.org/10.1016/j.ymeth.2014.01.021, 2014.

5. Minchao Wang, Wu Zhang, Wang Ding, Dongbo Dai, Huiran Zhang, Hao Xie, Luonan Chen, Yike Guo and Jiang Xie. Parallel Clustering Algorithm for Large-scale Biological Data Sets. PLoS One, 2014.

6. Doss C. Priya George, Chiranjib Chakraborty, SA Syed Haneef, Nagarajan NagaSundaram, Luonan Chen, Hailong Zhu. Evolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2). Theranostics, 2014.

7. Zhang Pengjun, Zou Meng, Wen Xinyu, Gu Feng, Li Juan, Liu Gaixia, Dong Jingxiao, Deng Xinxin, Gao Jing, Li Xiaolong, Jia Xingwang, Dong Zhennan, Chen Luonan,Wang Yong, and Tian Yaping. Development of Serum Parameters Panels for Early Detection of Pancreatic Cancer. International Journal of Cancer, 2014.

8. Meng Zou, Peng-Jun Zhang, Xin-Yu Wen, Luonan Chen, Ya-Ping Tian and Yong Wang. Identifying multi-biomarkers to distinguish malignant from benign colorectal tumours by a mixed integer programming. Journal of the American Medical Informatics Association, 2014.

9. Chiranjib Chakraborty, George Priya Doss. C, Luonan Chen, Hailong Zhu. Evaluating protein-protein interaction (PPI) networks using in silico pharmacology: to understand the diseases pathway, target discovery and drug-design. Current Protein and Peptide Science, 2013.

10. Xiangtan Yu, Guozheng Li, Luonan CHen. Prediction and early diagnosis of complex diseases by edge-network. Bioinformatics, doi:10.1093/bioinformatics/btt620，2013.

11. Tao Zeng, Shao-yan Sun, Yong Wang, Hailong Zhu, Luonan Chen. Network biomarkers reveal dysfunctional gene regulations during disease progression. FEBS Journal, doi:10.1111/febs.12536, 2013.

12. Yong Wang, Xiang-Sun Zhang, Luonan Chen. Computational systems biology in the big data era. BMC Systems Biology, doi:10.1186/1752-0509-7-S2-S1, 2013.

13. Rui Liu, Xiangdong Wang, Kazuyuki Aihara, Luonan Chen, Early diagnosis of complex diseases by molecular biomarkers, network biomarkers, and dynamical network biomarkers. Medicinal Research Reviews, DOI:10.1002/med.21293, 2013.

14. Shao-Yan Sun, Zhi-Ping Liu, Tao Zeng, Yong Wang, and Luonan Chen. Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks. Scientific Reports, DOI: 10.1038/srep02268, 2013.

15. Jiguang Wang, Yidan Sun, Si Zheng, Xiang-Sun Zhang, Huarong Zhou, and Luonan Chen. APG: an Active Protein-Gene Network Model to Quantify Regulatory Signals in Complex Biological Systems. Scientific Reports, DOI: 10.1038/srep01097, 2013.

16. Chao Zhang, Jiguang Wang, Kristina Hanspers, Dong Xu, Luonan Chen, Xiang-Sun Zhang, Alexander R. Pico. NOA: A Cytoscape Plugin for Network Ontology Analysis. Bioinformatics, 2013.

17. Xiaoping Liu, Xiaodong Zhang, Wei-Hua Tang, Luonan Chen and Xing-Ming Zhao. eFG: an electronic resource for Fusarium graminearum. Database, doi:10.1093/database/bat042, 2013.

18. Mingzhu Zhao, Hao-Teng Chang, Zhiping Liu, Luonan Chen, Dongqing Wei. Predicting Protein–Ligand Interactions Based on Chemical Preference Features with its Application to New D–Amino Acid Oxidase Inhibitor Discovery. Current Pharmaceutical Design, 2013.

19. Jiang Xie, Zhonghua Zhou, Kai Lu, Luonan Chen, Wu Zhang. Visualization of Biomolecular Networks Comparison on Cytoscape. Tsinghua Science and Technology, 2013.

20. Zikai Wu, Yong Wang, Luonan Chen. A New Framework for Drug Repositioning by Incorporating Functional Information. IET Systems Biology, 2013.

21. Meiyi Li, Tao Zeng, Yong Wang, Luonan Chen. Detecting tissue-specific early-warning signals for complex diseases based on dynamical network biomarkers: study of type-2 diabetes by cross-tissue analysis. Briefings in Bioinformatics, 2013.

22. Rui Liu, Kazuyuki Aihara, Luonan Chen. Dynamical network biomarkers for identifying critical transitions of biological processes. Quantitative Biology, DOI 10.1007/s40484-013-0008-0, 2013.

23. Songyot Nakariyakul, Zhi-Ping Liu, Luonan Chen. A Sequence-based Computational Approach to Predicting PDZ Domain-Peptide Interactions. BBA – Proteins and Proteomics, 2013.

24. Zikai Wu, Yong Wang, Luonan Chen. Network-Based Drug Repositioning. Molecular BioSystems, DOI:10.1039/C3MB25382A, 2013.

25. Chenglei Sun, Zheng-Zheng Shi, Xiaobo Zhou, Luonan Chen, Xing-Ming Zhao. Prediction of S-Glutathionylation Sites Based on Protein Sequences. PLoS ONE 8(2): e55512. doi:10.1371/journal.pone.0055512, 2013.

26. George Priya Doss C, Nagasundaram N, Chiranjib Chakraborty, Luonan Chen and Hailong Zhu. Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: A Molecular dynamics approach, Human Genomics, 2013.

27. Zhiyuan Yang, Yan Zhang, and Luonan Chen. Investigation of anti-cancer mechanisms by comparative analysis of naked mole rat and rat. BMC Systems Biology, 2013.

28. Zhi-Ping Liu, Wanwei Zhang, Katsuhisa Horimoto, and Luonan Chen. A Gaussian Graphical Model for Identifying Significantly Responsive Regulatory Networks from Time Course High-Throughput Data. IET Systems Biology, 2013.

29. Peipei Zhou, Shuiming Cai, Zengrong Liu, Luonan Chen, Ruiqi Wang. Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems. Chaos, Solitons & Fractals, 7242, 2013.