黄勋，博士，中国科学院遗传与发育生物学研究所研究员，博士生导师，分子发育生物学国家重点实验室副主任。

Email: xhuang@genetics.ac.cn

1994年获厦门大学学士学位，1997年获中国科学院微生物研究所硕士学位，2003年获美国加州大学圣克鲁斯分校(University of California, Santa Cruz)博士学位，同年进入美国斯坦福大学(Stanford University)从事博士后研究。2006年起任中国科学院遗传与发育生物学研究所研究员，博士生导师。入选中国科学院百人计划，2012年百人计划终期评估"优秀"。2014年获得国家杰出青年科学基金。

研究方向:　脂质是机体的重要组成成分，脂质代谢研究近年来逐渐成为生物学研究的前沿和热点。本实验室主要围绕着"脂质代谢调控"研究领域，利用模式动物体系，系统解析脂质代谢调控的分子机制及其所影响个体发育的分子细胞机理。

主要研究内容：1）在细胞、组织和个体层面，脂质代谢调控的分子机制。例如脂滴稳态是如何调控的？脂质储积与脂质使用的平衡是如何达到的？ 2）脂质代谢与个体发育的关系。脂质代谢如何与个体发育相协调？脂质代谢缺陷如何影响个体生长发育？ 3）脂质代谢相关疾病的发病、致病机理。 4）神经发育中的脂质代谢调控。

实验室网站：http://english.genetics.cas.cn/huangxun

1. Bi, J., Wang, W., Liu, Z., Huang, X., Jiang, Q., Liu, G., Wang, Y. and Huang, X. # (2014) Seipin promotes adipose tissue fat storage through the ER Ca2+-ATPase SERCA. Cell Metabolism 19: 861-871

2. Liu, Y., Wang, W., Shui, G. # and Huang, X. # (2014) CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway. PLoS Genetics 10(3): e1004172

3. Zhang, J., Li, X., Jevince, A., Guan, L., Wang, J., Hall, D., Huang, X. # and Ding, M. # (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics 9(6): e1003618

4. Ma, Z.*, Liu, Z.* and Huang, X. # (2012) Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Genetics 190(4):1299-1308

5. Zhou, B., Yang, L., Li, S., Huang, J., Chen, H., Hou, L., Wang, J., Green, C., Yan, Z., Huang, X., Kaeberlein, M., Zhu, L., Xiao, H., Liu, Y. and Han, J. # (2012) Midlife gene expressions identify modulators of aging through dietary interventions. PNAS 109(19):E1201-9

6. Bi, J. *, Xiang, Y. *, Chen, H., Liu, Z., Gronke, S., Kuhnlein, R. and Huang, X. # (2012) Opposite and redundant roles of the two Drosophila Perilipins in lipid mobilization. Journal of Cell Science 125:3568-77

7. Wang, C. and Huang, X. # (2012) Lipid metabolism and Drosophila sperm development. Sci China (Life Sciences) 55(1):35-40

8. Wang, C.*, Liu, Z.* and Huang, X. # (2012) Rab32 is important for autophagy and lipid storage in Drosophila. PLoS One 7(2):e32086

9. Zhang, P., Na, H., Liu, Z., Zhang, S., Xue, P., Chen, Y., Pu, J., Peng, G., Huang, X., Yang, F., Xie, Z., Xu, T., Xu, P., Ou, G., Zhang, S. and Liu, P. # (2012) Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets. Molecular and Cellular Proteomics 11(8):317-28

10. Wang, C., Ma, Z. Scott, M. P. and Huang, X. # (2011) The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. Developmental Biology 351:146-155

11. Tuxworth, RI., Chen, H., Vivancos, V., Carvajal, N., Huang, X. and Tear G. # (2011) The Batten disease gene CLN3 is required for the response to oxidative stress. Human Molecular Genetics 20:2037-47

12. Tian, Y. *, Bi, J. *, Shui, G., Liu, Z., Xiang, Y., Liu, Y., Wenk, M., Yang, H. and Huang, X. # (2011) Tissue-autonomous function of Drosophila Seipin in preventing ectopic lipid droplet formation. PLoS Genetics 7(4): e1001364

13．Fei, W., Shui, G., Zhang, Y., Krahmer, N., Ferguson, C., Kapterian, T., Lin, R., Dawes, I., Brown, A., Li, P., Huang, X., Parton, R., Wenk, M., Walther, T. and Yang, H. # (2011) A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genetics 7(7): e1002201

14. Song S.*, Ge Q.* , Wang J.*, Chen H., Tang S., Bi J., Li X., Xie Q. and Huang X.# (2011) TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance. J. Genetics and Genomics 38:1-11 (Cover story)

15. Chen, H., Liu, Z. and Huang, X. # (2010) Drosophila models of peroxisomal biogenesis disorder: Peroxins are required for spermatogenesis and very long chain fatty acid metabolism. Human Molecular Genetics 19:494-505

16. Xiang, Y., Liu, Z. and Huang, X. # (2010) br regulates the expression of the ecdysone biosynthesis gene npc1. Developmental Biology 344:800-808

17. Song, S.*, Zhang, B.*, Sun, H., Li, X., Xiang, Y., Liu, Z., Huang, X. # and Ding, M. # (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6(8): e1001056.

18. Ma, Z., Liu, Z. and Huang, X. # (2010) OSBP- and FAN- mediated sterol requirement for spermatogenesis in Drosophila. Development 137, 3775-3784

19.Chen, H., Ma, Z., Liu, Z., Tian,Y., Xiang, Y., Wang, C., Scott, M. P. and Huang, X.# (2009) Case studies of Ends-Out gene targeting in Drosophila. Genesis 47:305-308

20. Huang, X.,# Warren, J. and Gilbert, L.# (2008) New players in the regulation of ecdysone biosynthesis. J. Genetics and Genomics 35:1-10