焦保卫，中科院昆明动物所研究员，青年千人计划入选者。

Email: jiaobaowei@mail.kiz.ac.cn

长期从事发育及生殖生物学研究，鉴定了RLIM基因在乳腺发育中的关键作用，发现X染色体失活（XCI）在成体细胞中的新模式，阐明了RLIM基因在乳腺发育和胚胎发育早期中调控机制及其进化意义。还通过一系列新基因的发现和功能研究揭示了鱼类生殖生长的新格局。已经在Cell等杂志发表论文17篇。学科组将以小鼠等为对象研究发育与进化的遗传印迹调控，主要从事乳腺干细胞的调控、X染色体失活机制及进化意义、发育过程印迹基因的功能等研究。

个人网站：http://sourcedb.kiz.cas.cn/zw/zjrc/201306/t20130603_3854865.html

发表论文 (* denotes contribute equally to first author)

1. Shin J., Wallingford MC, Gallant J., Marcho C., Jiao B., Byron M., Bossenz M., Lawrence JB, Jones S., Mager J. & Bach I. 2013 Rnf12/RLIM is dispensable for X chromosome inactivation in the mouse embryonic epiblast. Nature. In press.

2. Jiao B, Güngör C, Johnsen SA, Peters MA, Taniguchi-Ishigaki N, Chen YW, Riethdorf S, Drung A, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC & Bach I. 2013. Nucleo-cytoplasmic shuttling regulates functional activity of Rnf12/RLIM. Mol Biol Cell. 2013 24(19):3085-96

3. Jiao B., Ma H., Shokhirev M., Drung A., Yang Q., Shin J., Lu S., Byron M., Kalantry S., Mercurio AM, Lawrence JB, Hoffmann A. and Bach I. 2012. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 149:630-41.

4. Li MH, Wu FR, Gu Y, Wang TR, Wang H, Yang SJ, Sun YL, Zhou LY, Huang XG, Jiao B, Cheng CH, Wang DS. 2012. Insulin-Like Growth Factor 3 Regulates Expression of Genes Encoding Steroidogenic Enzymes and Key Transcription Factors in the Nile Tilapia Gonad. Biology of Reproduction. 86:163, 1-10.

5. Shin J., Bossenz M., Chung Y., Ma H., Byron M., Taniguchi-Ishigaki N., Zhu X., Jiao B., Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB and Bach I. 2010. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 467:977-81.

6. Lin ZX, Jiao B., Che CT, Zuo Z, Mok CF, Zhao M, Ho WK, Tse WP, Lam KY, Fan RQ, Yang ZJ and Cheng CH. 2010. Ethyl acetate fraction of the root of Rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: potential application for psoriasis treatment. Phytotherapy Research. 24:1056-64.

7. Jiao B., Yeung E.K.C., Chan C.B. and Cheng C.H.K. 2008. Establishment of a transgenic yeast screening system for estrogenicity and identification of the anti-estrogenic activity of malachite green. Journal of Cellular Biochemistry.　105:1399-409.

8. Zhang Y., Liu Y., Huang X., Liu X., Jiao B., Meng Z., Zhu P., Li S., Lin H. and Cheng C.H.K. 2008. Two alternatively spliced GPR39 transcripts in seabream: molecular cloning, genomic organization, and regulation of gene expression by metabolic signals. Journal of Endocrinology. 199: 457-70.

9. Jiao B. and Cheng C.H.K. 2010. Disrupting actions of bisphenol A and malachite green on growth hormone receptor gene expression and signal transduction in seabream. Fish Physiology and Biochemistry. 36:251-61.

10. Wang D.S., Jiao B.*, Hu C., Huang X., Liu Z. and Cheng C.H.K. 2008. Discovery of a gonad-specific IGF subtype in teleost, Biochemical and Biophysical Research Communications. 367, 336-41.

11. Huang X., Jiao B.*, Fung K.K., Zhang Y., Chan C. B., Lin H., Wang D.S. and Cheng C.H.K. 2007. The presence of two distinct prolactin receptors with different signal pathways and constructive expression pattern under the stimulation of steroid hormones in teleost. Journal of Endocrinology. 194, 373-92.

12. Liu Z., Wu F., Jiao B.*, Zhang X., Hu C., Huang B., Zhou L., Huang X., Wang Z., Zhang Y., Nagahama Y., Cheng C.H.K. and Wang D.S. 2007. Molecular cloning of Dmrt1, Foxl2 and Cyp19 in Southern catfish and their possible roles in sex differentiation. Journal of Endocrinology 194, 223-41.

13. Jiao B., Huang X., Chan C.B., Zhang L., Wang D.S. and Cheng C.H.K. 2006. The co-existence of two growth hormone receptors in teleost fish and their differential signal transduction, tissue distribution and hormonal regulation of expression in seabream. Journal of Molecular Endocrinology 36, 23-40.